Reconstructing the phylogeny of glycopeptide biosynthetic gene clusters
نویسندگان
چکیده
منابع مشابه
Reconstructing Histories of Complex Gene Clusters on a Phylogeny
Clusters of genes that have evolved by repeated segmental duplication present difficult challenges throughout genomic analysis, from sequence assembly to functional analysis. These clusters are one of the major sources of evolutionary innovation, and they are linked to multiple diseases, including HIV and a variety of cancers. Understanding their evolutionary histories is a key to the applicati...
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Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal second...
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The exploration of the ancestral history, the phylogeny, of different species can raise valu-able information about their evolution. One approach for the reconstruction of phylogeneticscenarios or for the comparison of genomes is the examination of the genetic material on thelevel of the DNA, RNA or protein sequences. Another possibility is to study the genomicstructure. On this...
متن کاملReconstructing the Evolutionary History of Complex Human Gene Clusters
Clusters of genes that evolved from single progenitors via repeated segmental duplications present significant challenges to the generation of a truly complete human genome sequence. Such clusters can confound both accurate sequence assembly and downstream computational analysis, yet they represent a hotbed of functional innovation, making them of extreme interest. We have developed an algorith...
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This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of...
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ژورنال
عنوان ژورنال: Faktori eksperimental'noi evolucii organizmiv
سال: 1970
ISSN: 2415-3826,2219-3782
DOI: 10.7124/feeo.v20.744